3-Chlorobenzamide oxime - Names and Identifiers
3-Chlorobenzamide oxime - Physico-chemical Properties
Molecular Formula | C7H7ClN2O
|
Molar Mass | 170.6 |
Density | 1.36g/cm3 |
Melting Point | 115 °C |
Boling Point | 350.4°C at 760 mmHg |
Flash Point | 165.7°C |
Vapor Presure | 1.64E-05mmHg at 25°C |
Storage Condition | 2-8°C |
Refractive Index | 1.6 |
3-Chlorobenzamide oxime - Risk and Safety
Hazard Symbols | Xn - Harmful
|
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38 - Irritating to eyes, respiratory system and skin.
R44 - Risk of explosion if heated under confinement
|
Safety Description | S22 - Do not breathe dust.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
|
Hazard Note | Harmful |
Hazard Class | IRRITANT |
3-Chlorobenzamide oxime - Introduction
3-Chlorobenzamidoxime(3-Chlorobenzamidoxime) is an organic compound with the chemical formula C7H6ClN3O. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: 3-Chlorobenzamidoxime is a white crystalline powder.
-Melting point: About 162-164 ° C.
-Solubility: Soluble in hot alcohol and acid, insoluble in water.
-Molecular structure: Contains 1 chlorine atom and 1 hydroxyl group, which are combined with the amino group on the benzene ring.
Use:
3-Chlorobenzamidoxime has certain application value in organic synthesis and is commonly used in the following aspects:
-Metal chelating agent: It can form a stable complex with some metal ions for the separation and enrichment of metal ions.
-Heterocyclic synthesis: It can be used as an intermediate in synthetic chemistry to participate in the synthesis of heterocyclic compounds.
-Drug research: Its derivatives are used as precursors of some drugs or for drug analysis.
Method:
The preparation method of 3-Chlorobenzamidoxime can be achieved by the following steps:
1.3-chlorobenzoyl chloride is reacted with hydroxamic acid. The reaction is usually carried out at room temperature, and the reaction can be carried out using a non-aqueous solvent such as an alcohol or an ether.
2. After the reaction, the crystals of 3-chorobenzamidoxime are obtained by filtration, which can be crystallized and purified to finally obtain the desired product.
Safety Information:
- 3-Chlorobenzamidoxime is generally considered to be relatively safe under regular operating conditions.
-But as an organic compound, it still needs to follow laboratory safety procedures.
-When using or handling 3-chorobenzamidoxime, care should be taken to avoid contact with skin and eyes and maintain good ventilation.
-If necessary, wear suitable personal protective equipment such as protective gloves, safety glasses and protective masks.
Last Update:2024-04-09 02:00:44